Clinical Definition Esophagitis is a swelling and irritation of the esophagus. As a result, swallowing can be painful or difficult. Causes can include acid reflux, vomiting, medications, infections and an allergy-associated condition known as eosinophilic esophagitis. In Our Own Words Esophagitis is inflammation and irritation of the esophagus (i.e. the tube that transports liquids and…