Health A-Z


Clinical Definition

Cardiology, Emergency medicine, Internal medicine

In Our Own Words

Thrombosis refers to the formation of a blood clot (thrombus) either in a blood vessel or in one of the heart’s chambers. Often, this clot will develop in a vein deep in the body, called deep vein thrombosis, or DVT. Normally these clots occur in the lower leg, the thigh or the pelvic area, but can occur in other parts of the body as well.

When a thrombus breaks free and travels, it may cause a thromboembolism, which can be dangerous and life-threatening. It can journey to the lungs and lodge there, becoming a pulmonary embolism. DVT can result in complications in the leg, including chronic venous insufficiency or post-thrombotic syndrome. The affected leg can also experience pressure, chronic swelling or even ulcers. This can be a serious medical emergency.

Symptoms and Side Effects

  • Swelling or pain in an extremity
  • Feeling of warmth in swollen extremity
  • Skin redness
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